Genetics and Bioengineering (English)
Bachelor	TR-NQF-HE: Level 6	QF-EHEA: First Cycle	EQF-LLL: Level 6

General course introduction information

Course Code:

GBE421

Course Name:

Industrial Genetics and Bioengineering I

Course Semester:

Fall

Course Credits:

Theoretical	Practical	Credit	ECTS
2	6	5	10

Language of instruction:

Course Requisites:

Does the Course Require Work Experience?:

Type of course:

Compulsory

Course Level:

Bachelor

TR-NQF-HE:6. Master`s Degree

QF-EHEA:First Cycle

EQF-LLL:6. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator :

Dr.Öğr.Üyesi ELİF KUBAT ÖKTEM

Course Lecturer(s):

Course Assistants:

Course Objective and Content

Course Objectives:

The purpose of this course is to introduce the applications of genetics and bioengineering in different areas of industry.

At the end of this course the student will be able to:
• underline the importance of genetics and bioengineering in industry
• compare biological processes, organisms, or biotechnological systems to manufacture products
• discuss the methods of synthetic biology in biotech industry
• recognize the power of structural biology and protein engineering in industry
• define how process engineering is related with industrial bioengineering
• express the interaction between food engineering and bioengineering in industry
• recognize the relevance of energy engineering and biotechnology

Course Content:

• What is industrial biotechnology?
• Internship presentations of students
• What is genome modification?
• Genome modification in cell lines
• Zinc finger endonucleases
• TALEN (Tale Activator Like Effector Nuclease)
• How do you design your own TALEN?
• Example experiments
• CRISPR-Cas9 system
• How do you design your own TALEN?
• Example experiments
• Comparison of genome editing by zinc finger nucleases, TALEN and CRISPR-Cas9
• Explain synthetic biology and its industrial applications
• Explain structural biology and applied protein engineering
• Applied protein engineering in industrial genetics and bioengineering
• What is process engineering?
• Provide an overview of process engineering and its biotechnological applications in industry
• Explain waste treatment in biotechnological industry
• Provide an overview of food engineering and its biotechnological applications in industry
• Explain food and food additives produced by microbial biotechnology in industry
• Provide an overview of energy engineering and its biotechnological applications in industry

Learning Outcomes

The students who have succeeded in this course;

Learning Outcomes

1 - Knowledge
Theoretical - Conceptual
2 - Skills
Cognitive - Practical
3 - Competences
Communication and Social Competence
Learning Competence
Field Specific Competence
1) At the end of this course the student will be able to underline the importance of genetics and bioengineering in industry
Competence to Work Independently and Take Responsibility

Lesson Plan

Week	Subject	Related Preparation
1)	• What is industrial biotechnology?	-
1)	• Final Exam	-
2)	What is industrial biotechnology?	-
3)	• Internship presentations of students	-
4)	• What is genome modification? • Genome modification in cell lines • Zinc finger endonucleases • TALEN (Tale Activator Like Effector Nuclease) • How do you design your own TALEN? • Example experiments	-
5)	• CRISPR-Cas9 system • How do you design your own TALEN? • Example experiments • Comparison of genome editing by zinc finger nucleases, TALEN and CRISPR-Cas9	-
6)	• What is synthetic biology? • What are the industrial applications of synthetic biology?	-
7)	Midterm Exam I	-
8)	• What is structural biology? • Applied protein engineering in industrial genetics and bioengineering	-
9)	• Applied protein engineering in industrial genetics and bioengineering • What is process engineering?	-
10)	• Provide an overview of process engineering and its biotechnological applications in industry	-
11)	• Explain waste treatment in biotechnological industry	-
12)	• Provide an overview of food engineering and its biotechnological applications in industry	-
13)	• Explain food and food additives produced by microbial biotechnology in industry	-
14)	• Provide an overview of energy engineering and its biotechnological applications in industry	-

Sources

Course Notes / Textbooks:	• Introduction to Biotechnology, 3rd edition – Pearson. William J. Thieman and Michael A. Palladino
References:	• Introduction to Biotechnology, 3rd edition – Pearson. William J. Thieman and Michael A. Palladino

Course-Program Learning Outcome Relationship

Learning Outcomes	1
Program Outcomes
1) Sufficient knowledge in mathematics, science and engineering related to their branches; and the ability to apply theoretical and practical knowledge in these areas to model and solve engineering problems.
2) The ability to identify, formulate, and solve complex engineering problems; selecting and applying appropriate analysis and modeling methods for this purpose.
3) The ability to design a complex system, process, device or product under realistic constraints and conditions to meet specific requirements; the ability to apply modern design methods for this purpose. (Realistic constraints and conditions include such issues as economy, environmental issues, sustainability, manufacturability, ethics, health, safety, social and political issues, according to the nature of design.)
4) Ability to develop, select and use modern techniques and tools necessary for engineering applications; ability to use information technologies effectively.
5) Ability to design experiments, conduct experiments, collect data, analyze and interpret results to examine engineering problems or discipline-specific research topics.
6) The ability to work effectively in disciplinary and multidisciplinary teams; individual work skill.
7) Effective communication skills in Turkish oral and written communication; at least one foreign language knowledge; ability to write effective reports and understand written reports, to prepare design and production reports, to make effective presentations, to give and receive clear and understandable instructions.
8) Awareness of the need for lifelong learning; access to knowledge, ability to follow developments in science and technology, and constant self-renewal.
9) Conform to ethical principles, and standards of professional and ethical responsibility; be informed about the standards used in engineering applications.
10) Awareness of applications in business, such as project management, risk management and change management; awareness of entrepreneurship, and innovation; information about sustainable development.
11) Information about the universal and social health, environmental and safety effects of engineering applications and the ways in which contemporary problems are reflected in the engineering field; awareness of the legal consequences of engineering solutions.

Course - Learning Outcome Relationship

No Effect	1 Lowest	2 Low	3 Average	4 High	5 Highest

	Program Outcomes	Level of Contribution
1)	Sufficient knowledge in mathematics, science and engineering related to their branches; and the ability to apply theoretical and practical knowledge in these areas to model and solve engineering problems.
2)	The ability to identify, formulate, and solve complex engineering problems; selecting and applying appropriate analysis and modeling methods for this purpose.	1
3)	The ability to design a complex system, process, device or product under realistic constraints and conditions to meet specific requirements; the ability to apply modern design methods for this purpose. (Realistic constraints and conditions include such issues as economy, environmental issues, sustainability, manufacturability, ethics, health, safety, social and political issues, according to the nature of design.)	1
4)	Ability to develop, select and use modern techniques and tools necessary for engineering applications; ability to use information technologies effectively.	1
5)	Ability to design experiments, conduct experiments, collect data, analyze and interpret results to examine engineering problems or discipline-specific research topics.
6)	The ability to work effectively in disciplinary and multidisciplinary teams; individual work skill.	1
7)	Effective communication skills in Turkish oral and written communication; at least one foreign language knowledge; ability to write effective reports and understand written reports, to prepare design and production reports, to make effective presentations, to give and receive clear and understandable instructions.	1
8)	Awareness of the need for lifelong learning; access to knowledge, ability to follow developments in science and technology, and constant self-renewal.	1
9)	Conform to ethical principles, and standards of professional and ethical responsibility; be informed about the standards used in engineering applications.
10)	Awareness of applications in business, such as project management, risk management and change management; awareness of entrepreneurship, and innovation; information about sustainable development.	1
11)	Information about the universal and social health, environmental and safety effects of engineering applications and the ways in which contemporary problems are reflected in the engineering field; awareness of the legal consequences of engineering solutions.	1

Learning Activity and Teaching Methods

Expression
Brainstorming/ Six tihnking hats
Lesson
Application (Modelling, Design, Model, Simulation, Experiment etc.)

Assessment & Grading Methods and Criteria

Written Exam (Open-ended questions, multiple choice, true-false, matching, fill in the blanks, sequencing)
Reporting

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Attendance	15	% 10
Midterms	1	% 40
Final	1	% 50
total		% 100
PERCENTAGE OF SEMESTER WORK		% 50
PERCENTAGE OF FINAL WORK		% 50
total		% 100

Workload and ECTS Credit Grading

Activities	Number of Activities	Duration (Hours)	Workload
Course Hours	15	2	30
Laboratory	15	6	90
Midterms	1	2	2
Final	1	2	2
Total Workload			124