Genetics and Bioengineering (English)
Bachelor	TR-NQF-HE: Level 6	QF-EHEA: First Cycle	EQF-LLL: Level 6

General course introduction information

Course Code:

GBE102

Course Name:

Molecular Cell Biology I

Course Semester:

Fall

Course Credits:

Theoretical	Practical	Credit	ECTS
2	0	2	8

Language of instruction:

Course Requisites:

Does the Course Require Work Experience?:

Type of course:

Compulsory

Course Level:

Bachelor

TR-NQF-HE:6. Master`s Degree

QF-EHEA:First Cycle

EQF-LLL:6. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator :

Dr.Öğr.Üyesi FATMA TUBA AKDENİZ

Course Lecturer(s):

Dr.Öğr.Üyesi FATMA TUBA AKDENİZ

Course Assistants:

Course Objective and Content

Course Objectives:

The aim of this course to provide the introduction knowledge to bioengineers necessary to discuss the basics and applications of molecular biology and cellular biology.

Course Content:

Describe the basics of molecular biology, explain the basic processes of molecular cell biology, describe the terminology of life sciences, describe the cellular matrices and discuss how important they are for living cells, explain basic structures and of functions of cellular membranes, describe role of cytoskeleton and how it interacts with cellular components , review the roles of organelles, describe energy production and types of energy productions in cells, describe the communication and transport in/between cells.

Learning Outcomes

The students who have succeeded in this course;

Learning Outcomes

1 - Knowledge
Theoretical - Conceptual
1) The student is able to describe the basics of molecular biology
2 - Skills
Cognitive - Practical
3 - Competences
Communication and Social Competence
Learning Competence
Field Specific Competence
1) The student is able to explain the basic processes of molecular cell biology
2) The student is able to describe the terminology of life sciences
3) The student is able to describe the cellular matrices and discuss how important they are for living cells
4) The student is able to explain basic structures and of functions of cellular membranes
5) The student is able to describe role of cytoskeleton and how it interacts with cellular components
6) The student is able to review the roles of organelles
7) The student is able to describe energy production and types of energy productions in cells
8) The student is able to describe the communication and transport in/between cells
Competence to Work Independently and Take Responsibility

Lesson Plan

Week	Subject	Related Preparation
1)	• Syllabus • Introduction of molecular Cell Biology • Themes in the study of life • The theory of natural selection • Study types in life sciences	Lecture notes and powerpoint presentation
2)	• Discuss the specific properties of extracellular matrix • Describe the components of extracellular matrix: proteoglycans, fibrous proteins, other as fibronectin and laminin • Describe the cell adhesion to extracellular matrix • Discuss the cell adhesion molecules • Describe the diseases related with cell adhesion	Lecture notes and powerpoint presentation
3)	• Describe the biological membranes. • Explain the functions of biological membranes. • Define the membrane components: lipid, protein and carbonhydrates	Lecture notes and powerpoint presentation
4)	• Describe the cytoskeleton • Explain the members of cytoskeleton: microfilaments, intermediate filaments and microtubules • Discuss the differences between the members of cytoskeleton • Explain the abnormalities related with cytoskeleton	Lecture notes and powerpoint presentation
5)	• Describe the organelles: Nucleus, ER, ribosomes, golgi apparatus, lysosomes, mitochondria, vacuoles, cilia and flagella, cell wall, plastids, central vacuole • Define the works organelles do • Discuss the compression between prokaryotic and eukaryotic cells • Discuss the differences between plant and animal cells	Lecture notes and powerpoint presentation
6)	• Describe the transport from cell membrane • Explain the transport types: passive diffusion, active&co-transport, • Define membrane selectivity • Discuss the intracellular transport	Lecture notes and powerpoint presentation
7)	• Describe the cell cycle • Explain the cell cycle phases: G0 phase, interphase and mitotic phase • Discuss the molecules and enzymes that involved in specific phases and specific replication processes • Define cell division types: meiosis and mitosis • Discuss the differences between meiosis and mitosis • Discuss the differences between plant and animal cell divisions	Lecture notes and powerpoint presentation
8)	Midterm I	-
9)	• Describe the cell cycle regulation • Define main regulators of cell cycle: cyclins, cyclin-dependent kinases, cell cycle inhibitors • Explain the phases that cell cycle regulators affect • Discuss the anomalies related with cell cycle regulation	Lecture notes and powerpoint presentation
10)	• Define photosynthesis • Describe the history of photosynthesis studies • Discuss the evolutionary history of photosynthesis • Defined cell compartments that photosynthesis steps take place • Describe C3, C4 and CAM plants and discuss the differences between them • Describe the factors that affect the rate of photosynthesis	Lecture notes and powerpoint presentation
11)	Midterm II	-
12)	• Describe the ATP synthesis • Describe the cellular respiration • Define glycolysis • Define aerobic and anaerobic respirations • Define lactic acid and ethyl alcohol respiration	Lecture notes and powerpoint presentation
13)	• Describe aerobic cellular respiration • Define the steps of cellular respiration: glycolysis, krebs cycle and electron transport system • Compare the differences between aerobic and anaerobic cellular respiration • Types of phosphorylations: oxidative and substrate level	Lecture notes and powerpoint presentation
14)	• Discuss the cell internet • Define the evolution of cell signaling • Describe the local and long distance signaling • Define the stages of cell signaling	Lecture notes and powerpoint presentation
15)	Final Exam	-

Sources

Course Notes / Textbooks:	Lecture notes and power point presentations Hardin, J., Bertoni, G., Kleinsmith, L. J., & Becker, W. M. (2012). Becker's world of the cell (8th ed.). Boston: Benjamin Cummings. Campbell Biology (10th Edition), by Jane B. Reecee, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson, ISBN-13: 978-0321775658 ISBN-10: 0321775651 Edition: 10th
References:	Lecture notes and power point presentations Hardin, J., Bertoni, G., Kleinsmith, L. J., & Becker, W. M. (2012). Becker's world of the cell (8th ed.). Boston: Benjamin Cummings. Campbell Biology (10th Edition), by Jane B. Reecee, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson, ISBN-13: 978-0321775658 ISBN-10: 0321775651 Edition: 10th

Course-Program Learning Outcome Relationship

Learning Outcomes	1	2	3	4	5	6	7	8	9
Program Outcomes
1) Sufficient knowledge in mathematics, science and engineering related to their branches; and the ability to apply theoretical and practical knowledge in these areas to model and solve engineering problems.
2) The ability to identify, formulate, and solve complex engineering problems; selecting and applying appropriate analysis and modeling methods for this purpose.
3) The ability to design a complex system, process, device or product under realistic constraints and conditions to meet specific requirements; the ability to apply modern design methods for this purpose. (Realistic constraints and conditions include such issues as economy, environmental issues, sustainability, manufacturability, ethics, health, safety, social and political issues, according to the nature of design.)
4) Ability to develop, select and use modern techniques and tools necessary for engineering applications; ability to use information technologies effectively.
5) Ability to design experiments, conduct experiments, collect data, analyze and interpret results to examine engineering problems or discipline-specific research topics.
6) The ability to work effectively in disciplinary and multidisciplinary teams; individual work skill.
7) Effective communication skills in Turkish oral and written communication; at least one foreign language knowledge; ability to write effective reports and understand written reports, to prepare design and production reports, to make effective presentations, to give and receive clear and understandable instructions.
8) Awareness of the need for lifelong learning; access to knowledge, ability to follow developments in science and technology, and constant self-renewal.
9) Conform to ethical principles, and standards of professional and ethical responsibility; be informed about the standards used in engineering applications.
10) Awareness of applications in business, such as project management, risk management and change management; awareness of entrepreneurship, and innovation; information about sustainable development.
11) Information about the universal and social health, environmental and safety effects of engineering applications and the ways in which contemporary problems are reflected in the engineering field; awareness of the legal consequences of engineering solutions.

Course - Learning Outcome Relationship

No Effect	1 Lowest	2 Low	3 Average	4 High	5 Highest

	Program Outcomes	Level of Contribution
1)	Sufficient knowledge in mathematics, science and engineering related to their branches; and the ability to apply theoretical and practical knowledge in these areas to model and solve engineering problems.	2
2)	The ability to identify, formulate, and solve complex engineering problems; selecting and applying appropriate analysis and modeling methods for this purpose.	1
3)	The ability to design a complex system, process, device or product under realistic constraints and conditions to meet specific requirements; the ability to apply modern design methods for this purpose. (Realistic constraints and conditions include such issues as economy, environmental issues, sustainability, manufacturability, ethics, health, safety, social and political issues, according to the nature of design.)	1
4)	Ability to develop, select and use modern techniques and tools necessary for engineering applications; ability to use information technologies effectively.	1
5)	Ability to design experiments, conduct experiments, collect data, analyze and interpret results to examine engineering problems or discipline-specific research topics.
6)	The ability to work effectively in disciplinary and multidisciplinary teams; individual work skill.
7)	Effective communication skills in Turkish oral and written communication; at least one foreign language knowledge; ability to write effective reports and understand written reports, to prepare design and production reports, to make effective presentations, to give and receive clear and understandable instructions.
8)	Awareness of the need for lifelong learning; access to knowledge, ability to follow developments in science and technology, and constant self-renewal.	1
9)	Conform to ethical principles, and standards of professional and ethical responsibility; be informed about the standards used in engineering applications.
10)	Awareness of applications in business, such as project management, risk management and change management; awareness of entrepreneurship, and innovation; information about sustainable development.
11)	Information about the universal and social health, environmental and safety effects of engineering applications and the ways in which contemporary problems are reflected in the engineering field; awareness of the legal consequences of engineering solutions.

Learning Activity and Teaching Methods

Expression
Brainstorming/ Six tihnking hats
Lesson
Q&A / Discussion

Assessment & Grading Methods and Criteria

Written Exam (Open-ended questions, multiple choice, true-false, matching, fill in the blanks, sequencing)
Presentation

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Presentation	1	% 10
Midterms	2	% 50
Final	1	% 40
total		% 100
PERCENTAGE OF SEMESTER WORK		% 60
PERCENTAGE OF FINAL WORK		% 40
total		% 100

Workload and ECTS Credit Grading

Activities	Number of Activities	Duration (Hours)	Workload
Course Hours	0	30	0
Presentations / Seminar	1	1	1
Midterms	2	3	6
Final	1	2	2
Total Workload			9