Genetics and Bioengineering (English)
Bachelor	TR-NQF-HE: Level 6	QF-EHEA: First Cycle	EQF-LLL: Level 6

General course introduction information

Course Code:

GBE201

Course Name:

Molecular Cell Biology II

Course Semester:

Fall

Course Credits:

Theoretical	Practical	Credit	ECTS
2	2	3	5

Language of instruction:

Course Requisites:

Does the Course Require Work Experience?:

Type of course:

Compulsory

Course Level:

Bachelor

TR-NQF-HE:6. Master`s Degree

QF-EHEA:First Cycle

EQF-LLL:6. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator :

Dr.Öğr.Üyesi FATMA TUBA AKDENİZ

Course Lecturer(s):

Dr.Öğr.Üyesi FATMA TUBA AKDENİZ
Dr.Öğr.Üyesi METİN YAZAR

Course Assistants:

Course Objective and Content

Course Objectives:

The purpose of this course is to provide the detailed knowledge necessary to understand the mechanisms of molecular and cellular biology.

Course Content:

Define the detailed structure and function of DNA, explain the mechanisms of chromosomal DNA packaging, discuss genome organization, define DNA replication, repair and recombination, explain how cells read the genome: from DNA to protein, indicate the similarities and differences of transcription and translation mechanisms in prokaryotes and eukaryotes, identify gene expression control mechanisms, underline epigenetics, explain the cell cycle and justify the importance of cell-cycle control system, differentiate cell death mechanisms, describe and differentiate most commonly used molecular biology techniques.

Learning Outcomes

The students who have succeeded in this course;

Learning Outcomes

1 - Knowledge
Theoretical - Conceptual
2 - Skills
Cognitive - Practical
3 - Competences
Communication and Social Competence
Learning Competence
Field Specific Competence
1) • DNA'nın ayrıntılı yapısını ve işlevini tanımlama
2) • discuss genome organization
3) • explain how cells read the genome: from DNA to protein
4) • identify gene expression control mechanisms
5) • underline epigenetics
6) • explain the cell cycle and justify the importance of cell-cycle control system
7) • differentiate cell death mechanisms
8) • describe and differentiate most commonly used molecular biology techniques
Competence to Work Independently and Take Responsibility

Lesson Plan

Week	Subject	Related Preparation
1)	• Explain the course • Explain molecular biology and genetics in a general perspective	-
2)	• Introduction to the cell • DNA, RNA, proteins in general • Cell Chemistry in general	-
2)	• The structure and function of DNA	-
4)	• How eukaryotic DNA is packed? • Nucleosome structure • Differences between euchromatin and heterochromatin • Global structure of chromosomes	-
5)	• DNA replication mechanisms • The initiation and completion of DNA replication in chromosomes • DNA repair • Homologous recombination	-
6)	• The structure and function of RNA • How does RNA polymerase work? • Transcription • Differences of transcription in prokaryotes and eukaryotes • RNA processing	-
7)	• Reading frames • Structure of ribosome • tRNA, amino asil tRNA and polypeptidiltRNAs • Translation	-
8)	Midterm I	-
9)	• Chaperones • Protein folding • Proteasomal degradation	-
10)	• An overview of gene control • Control of transcription by sequence specific DNA-binding proteins • Types of DNA-binding proteins • How do transcriptional regulators turn genes on and off?	-
11)	• Genetic mechanisms that create and maintain specialized cell types • Mechanisms that reinforce cell memory in plants and animals • Post-transcriptional gene control • Regulation of gene expression by non-coding RNAs	-
12)	• Overview of the cell cycle • The cell cycle control system • S-Phase-Mitosis-Cytokinesis • Control of cell division and cell growth	-
13)	Midterm II	-
14)	• Apoptosis • Autophagy • Necrosis	-
15)	Final Exam	-

Sources

Course Notes / Textbooks:	• Molecular Biology of The Cell, 6th edition – Garland Science. Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts and Peter Walter • Molecular Cell Biology, 7th edition – WHFreeman. Harvey Lodish, Arnold Berk, S Lawrence Zipursky, Paul Matsudaira, David Baltimore, and James Darnell.
References:	• Molecular Biology of The Cell, 6th edition – Garland Science. Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts and Peter Walter • Molecular Cell Biology, 7th edition – WHFreeman. Harvey Lodish, Arnold Berk, S Lawrence Zipursky, Paul Matsudaira, David Baltimore, and James Darnell.

Course-Program Learning Outcome Relationship

Learning Outcomes	1	2	3	4	5	6	7	8
Program Outcomes
1) Sufficient knowledge in mathematics, science and engineering related to their branches; and the ability to apply theoretical and practical knowledge in these areas to model and solve engineering problems.
2) The ability to identify, formulate, and solve complex engineering problems; selecting and applying appropriate analysis and modeling methods for this purpose.
3) The ability to design a complex system, process, device or product under realistic constraints and conditions to meet specific requirements; the ability to apply modern design methods for this purpose. (Realistic constraints and conditions include such issues as economy, environmental issues, sustainability, manufacturability, ethics, health, safety, social and political issues, according to the nature of design.)
4) Ability to develop, select and use modern techniques and tools necessary for engineering applications; ability to use information technologies effectively.
5) Ability to design experiments, conduct experiments, collect data, analyze and interpret results to examine engineering problems or discipline-specific research topics.
6) The ability to work effectively in disciplinary and multidisciplinary teams; individual work skill.
7) Effective communication skills in Turkish oral and written communication; at least one foreign language knowledge; ability to write effective reports and understand written reports, to prepare design and production reports, to make effective presentations, to give and receive clear and understandable instructions.
8) Awareness of the need for lifelong learning; access to knowledge, ability to follow developments in science and technology, and constant self-renewal.
9) Conform to ethical principles, and standards of professional and ethical responsibility; be informed about the standards used in engineering applications.
10) Awareness of applications in business, such as project management, risk management and change management; awareness of entrepreneurship, and innovation; information about sustainable development.
11) Information about the universal and social health, environmental and safety effects of engineering applications and the ways in which contemporary problems are reflected in the engineering field; awareness of the legal consequences of engineering solutions.

Course - Learning Outcome Relationship

No Effect	1 Lowest	2 Low	3 Average	4 High	5 Highest

	Program Outcomes	Level of Contribution
1)	Sufficient knowledge in mathematics, science and engineering related to their branches; and the ability to apply theoretical and practical knowledge in these areas to model and solve engineering problems.	3
2)	The ability to identify, formulate, and solve complex engineering problems; selecting and applying appropriate analysis and modeling methods for this purpose.	1
3)	The ability to design a complex system, process, device or product under realistic constraints and conditions to meet specific requirements; the ability to apply modern design methods for this purpose. (Realistic constraints and conditions include such issues as economy, environmental issues, sustainability, manufacturability, ethics, health, safety, social and political issues, according to the nature of design.)	1
4)	Ability to develop, select and use modern techniques and tools necessary for engineering applications; ability to use information technologies effectively.	1
5)	Ability to design experiments, conduct experiments, collect data, analyze and interpret results to examine engineering problems or discipline-specific research topics.	1
6)	The ability to work effectively in disciplinary and multidisciplinary teams; individual work skill.
7)	Effective communication skills in Turkish oral and written communication; at least one foreign language knowledge; ability to write effective reports and understand written reports, to prepare design and production reports, to make effective presentations, to give and receive clear and understandable instructions.	1
8)	Awareness of the need for lifelong learning; access to knowledge, ability to follow developments in science and technology, and constant self-renewal.
9)	Conform to ethical principles, and standards of professional and ethical responsibility; be informed about the standards used in engineering applications.
10)	Awareness of applications in business, such as project management, risk management and change management; awareness of entrepreneurship, and innovation; information about sustainable development.
11)	Information about the universal and social health, environmental and safety effects of engineering applications and the ways in which contemporary problems are reflected in the engineering field; awareness of the legal consequences of engineering solutions.

Learning Activity and Teaching Methods

Expression
Brainstorming/ Six tihnking hats
Lesson
Lab
Report Writing
Application (Modelling, Design, Model, Simulation, Experiment etc.)

Assessment & Grading Methods and Criteria

Written Exam (Open-ended questions, multiple choice, true-false, matching, fill in the blanks, sequencing)
Presentation
Reporting

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Homework Assignments	5	% 10
Midterms	2	% 50
Final	1	% 40
total		% 100
PERCENTAGE OF SEMESTER WORK		% 60
PERCENTAGE OF FINAL WORK		% 40
total		% 100

Workload and ECTS Credit Grading

Activities	Number of Activities	Duration (Hours)	Workload
Course Hours	15	2	30
Application	15	2	30
Midterms	2	3	6
Final	1	2	2
Total Workload			68