| Genetics and Bioengineering (English) | |||||
| Bachelor | TR-NQF-HE: Level 6 | QF-EHEA: First Cycle | EQF-LLL: Level 6 | ||
| Course Code: | GBE301 | ||||||||
| Course Name: | Cell and Tissue Engineering | ||||||||
| Course Semester: | Fall | ||||||||
| Course Credits: |
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| Language of instruction: | EN | ||||||||
| Course Requisites: | |||||||||
| Does the Course Require Work Experience?: | No | ||||||||
| Type of course: | Compulsory | ||||||||
| Course Level: |
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| Mode of Delivery: | Face to face | ||||||||
| Course Coordinator : | Dr.Öğr.Üyesi ÖZGE ACAR | ||||||||
| Course Lecturer(s): |
Dr.Öğr.Üyesi METİN YAZAR Dr.Öğr.Üyesi ÖZGE ACAR |
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| Course Assistants: |
| Course Objectives: | This course is designated to provide the introduction knowledge to bioengineers necessary to discuss the basics and applications of cell and tissue engineering. At the end of this course the student will be able to: • To discuss the terms of cell and tissue engineering, recognize its applications • To describe the subjects, tools and protocols used in cell and tissue engineering • To explain the characteristics of cells, tissues and microenvironments used for tissue engineering • To describe the technological requirements for in vitro cell, tissue and biomaterial development. • To explain molecular and cellular engineering • To describe the applications of cell andf tisssue engineering in medicine and recognize the complications • To understand the ethical, legal and quality aspects of cell and tissue engineering applications |
| Course Content: | Goresel medya bilesenleri |
The students who have succeeded in this course;
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| Week | Subject | Related Preparation |
| 1) | • Regenerative medicine applications in organ transplantation, orthopedics, cardiovascular surgery,dentistry, plastic surgery, neurosurgery, burns. | - |
| 2) | • Syllabus • History of tissue engineeering • Challanges facing tissue engineering • Cell and Tissue Engineering applications | - |
| 3) | • Factors controlling cell proliferation • Review of signal transduction pathways • Review of cell cycle controls | - |
| 4) | • Extracellular matrix molecules and ligands • Inductive phenomenon • Morphogenesis Dynamics of Cell-Matrix interactions | - |
| 5) | • Tissue types and characteristics • Cell culture types and conditions | - |
| 6) | Growth factors Regulation of cell behaviour by matrix proteins Tissue culture on biomaterials | - |
| 7) | • Cell patterning • Adhesive non adhesive materials • Cell interactions with materials • Scaffolds | - |
| 8) | • Midterm | - |
| 9) | • Industrial applications of cell cultures | - |
| 10) | • Genetically designed tissues • Posttranscriptional gene silencing • Knockout and CRISPR technologies • Fetal tissue engineering • Stem cells | - |
| 11) | • Perfusion and hydrodynamics • Angiogenesis • İnnate and adaptive immune responses in tissue engineering | - |
| 13) | • Perfusion and hydrodynamics • Angiogenesis • İnnate and adaptive immune responses in tissue engineering | - |
| 14) | • Ethical issues • Quality management • Regulations | - |
| 15) | • Final Exam | - |
| Course Notes / Textbooks: | • Principles of Tissue Engineering. R.Lanza, R.Langer, J.P.Vacanti. Academic Press. • Fundamentals of Tissue Engineering. U.Meyer, T.Meyer, J.Handschel, H.P.Wiesmann. |
| References: | • Principles of Tissue Engineering. R.Lanza, R.Langer, J.P.Vacanti. Academic Press. • Fundamentals of Tissue Engineering. U.Meyer, T.Meyer, J.Handschel, H.P.Wiesmann. |
| Learning Outcomes | 1 |
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| Program Outcomes | ||||||||||
| 1) Sufficient knowledge in mathematics, science and engineering related to their branches; and the ability to apply theoretical and practical knowledge in these areas to model and solve engineering problems. | ||||||||||
| 2) The ability to identify, formulate, and solve complex engineering problems; selecting and applying appropriate analysis and modeling methods for this purpose. | ||||||||||
| 3) The ability to design a complex system, process, device or product under realistic constraints and conditions to meet specific requirements; the ability to apply modern design methods for this purpose. (Realistic constraints and conditions include such issues as economy, environmental issues, sustainability, manufacturability, ethics, health, safety, social and political issues, according to the nature of design.) | ||||||||||
| 4) Ability to develop, select and use modern techniques and tools necessary for engineering applications; ability to use information technologies effectively. | ||||||||||
| 5) Ability to design experiments, conduct experiments, collect data, analyze and interpret results to examine engineering problems or discipline-specific research topics. | ||||||||||
| 6) The ability to work effectively in disciplinary and multidisciplinary teams; individual work skill. | ||||||||||
| 7) Effective communication skills in Turkish oral and written communication; at least one foreign language knowledge; ability to write effective reports and understand written reports, to prepare design and production reports, to make effective presentations, to give and receive clear and understandable instructions. | ||||||||||
| 8) Awareness of the need for lifelong learning; access to knowledge, ability to follow developments in science and technology, and constant self-renewal. | ||||||||||
| 9) Conform to ethical principles, and standards of professional and ethical responsibility; be informed about the standards used in engineering applications. | ||||||||||
| 10) Awareness of applications in business, such as project management, risk management and change management; awareness of entrepreneurship, and innovation; information about sustainable development. | ||||||||||
| 11) Information about the universal and social health, environmental and safety effects of engineering applications and the ways in which contemporary problems are reflected in the engineering field; awareness of the legal consequences of engineering solutions. | ||||||||||
| No Effect | 1 Lowest | 2 Low | 3 Average | 4 High | 5 Highest |
| Program Outcomes | Level of Contribution | |
| 1) | Sufficient knowledge in mathematics, science and engineering related to their branches; and the ability to apply theoretical and practical knowledge in these areas to model and solve engineering problems. | 2 |
| 2) | The ability to identify, formulate, and solve complex engineering problems; selecting and applying appropriate analysis and modeling methods for this purpose. | 1 |
| 3) | The ability to design a complex system, process, device or product under realistic constraints and conditions to meet specific requirements; the ability to apply modern design methods for this purpose. (Realistic constraints and conditions include such issues as economy, environmental issues, sustainability, manufacturability, ethics, health, safety, social and political issues, according to the nature of design.) | 1 |
| 4) | Ability to develop, select and use modern techniques and tools necessary for engineering applications; ability to use information technologies effectively. | 1 |
| 5) | Ability to design experiments, conduct experiments, collect data, analyze and interpret results to examine engineering problems or discipline-specific research topics. | |
| 6) | The ability to work effectively in disciplinary and multidisciplinary teams; individual work skill. | 1 |
| 7) | Effective communication skills in Turkish oral and written communication; at least one foreign language knowledge; ability to write effective reports and understand written reports, to prepare design and production reports, to make effective presentations, to give and receive clear and understandable instructions. | |
| 8) | Awareness of the need for lifelong learning; access to knowledge, ability to follow developments in science and technology, and constant self-renewal. | 1 |
| 9) | Conform to ethical principles, and standards of professional and ethical responsibility; be informed about the standards used in engineering applications. | |
| 10) | Awareness of applications in business, such as project management, risk management and change management; awareness of entrepreneurship, and innovation; information about sustainable development. | |
| 11) | Information about the universal and social health, environmental and safety effects of engineering applications and the ways in which contemporary problems are reflected in the engineering field; awareness of the legal consequences of engineering solutions. |
| Expression | |
| Brainstorming/ Six tihnking hats | |
| Lab | |
| Application (Modelling, Design, Model, Simulation, Experiment etc.) |
| Written Exam (Open-ended questions, multiple choice, true-false, matching, fill in the blanks, sequencing) |
| Semester Requirements | Number of Activities | Level of Contribution |
| Midterms | 1 | % 50 |
| Final | 1 | % 50 |
| total | % 100 | |
| PERCENTAGE OF SEMESTER WORK | % 50 | |
| PERCENTAGE OF FINAL WORK | % 50 | |
| total | % 100 | |
| Activities | Number of Activities | Duration (Hours) | Workload |
| Course Hours | 15 | 2 | 30 |
| Laboratory | 15 | 4 | 60 |
| Midterms | 1 | 2 | 2 |
| Final | 1 | 2 | 2 |
| Total Workload | 94 | ||