ISTANBUL OKAN UNIVERSITY INFORMATION PACKAGE / COURSE CATALOGUE
| Computer Engineering | |||||
| Bachelor | TR-NQF-HE: Level 6 | QF-EHEA: First Cycle | EQF-LLL: Level 6 | ||
General course introduction information
| Course Code: | GBM404 | ||||||||
| Course Name: | Immunology | ||||||||
| Course Semester: | Fall | ||||||||
| Course Credits: |
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| Language of instruction: | TR | ||||||||
| Course Requisites: | |||||||||
| Does the Course Require Work Experience?: | No | ||||||||
| Type of course: | Compulsory | ||||||||
| Course Level: |
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| Mode of Delivery: | Face to face | ||||||||
| Course Coordinator : | Dr.Öğr.Üyesi ELİF KUBAT ÖKTEM | ||||||||
| Course Lecturer(s): | |||||||||
| Course Assistants: |
Course Objective and Content
| Course Objectives: | This course is designated to provide the introduction knowledge to bioengineers necessary to discuss the basics and applications of immunology. At the end of this course the student will be able to: • To discuss the terms of immunology • To understand the basics of adaptive and innate immune system • To explain the differences between adaptive and innate immune system • To discuss the members of innate and adaptive immune system • To describe the molecular structure of MHC and antibodies • To explain the antigen processing and presentation pathways • To discuss the maturation, activation and regulation of lymphocytes • To explain the effector mechanisms of immune responses • To describe the the immune system in defense and disease: hypersensitivity, tumor immunity, transplantation immunity |
| Course Content: | • Define immunology • Highlight the milestones of immunology. • Describe The Innate Immunity • Describe The Cells and Tissues Of The Adaptive Immune System • Describe Antibodies and Antigens • Describe The Major Histocompatibility Complex • Describe Antigen Receptors and Accessory Molecules of T Lymphocytes • Describe Lymphocyte Development and The Rearrangement and Expression Of Antigen Receptor Genes • Describe Immunological Tolerance • Describe Cytokines • Describe Immunity to Microbes • Describe The Mechanism of Translation • Describe The Transplantation Immunology • Describe Immunity To Tumors |
Learning Outcomes
The students who have succeeded in this course;
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Lesson Plan
| Week | Subject | Related Preparation |
| 1) | • Syllabus • Milestones of Science of Immunology • Basic Terminologies of Immunology • Introduction to concepts of Innate and Adaptive Immunity | - |
| 2) | • Discuss the specific properties of innate immunity • Describe the features of innate immune recognition • Describe the components of the innate immunity • Discuss the role of innate immunity in stimulating adaptive immune responses | - |
| 3) | • Describe the cells of the adaptive immune system • Explain the anatomy and functions of lymphoid tissues • Define the pathways and mechanisms of lymphocyte recirculation and homing | - |
| 4) | • Describe the natural distribution and production of antibodies • Define the molecular structure of antibodies • Explain the antibody binding of antigens • Discuss structure-function relationships in antibody molecules | - |
| 5) | • Describe the discovery of the MHC and its role in immune responses • Define the structure of MHC molecules • Discuss binding of peptides to MHC molecules • Explain the genomic organization and expression of the MHC | - |
| 6) | • Describe αβ-TCR for MHC-associated peptide antigen, • Explain CD3 and zeta proteins of the TCR complex • Define; • antigen receptors of γδ T cells • antigen receptors of γδ T cells, • antigen receptors of NK-T cells, • coreceptors and costimulatory receptors on T cells, • CD4 and CD8: coreceptors involved in MHC-restricted T cell activation. • Explain the structure and functions of CD4 and CD8 • Explain the costimulatory and inhibitory receptors of the cd28 family • Explain CD2 and the slam family of costimulatory receptors | - |
| 7) | • Midterm Exam | - |
| 8) | • Repeat overview of lymphocyte development • Describe the rearrangement of antigen receptor genes in band T lymphocytes • Explain B lymphocyte development • Discuss the maturation of T lymphocytes | - |
| 9) | • Describe general features and mechanisms of immunological tolerance • Define T lymphocyte tolerance • Define B lymphocyte tolerance • Explain tolerance induced by foreign protein antigens • Discuss the Homeostasis in the immune system: Termination of normal immune responses | - |
| 10) | • Define general properties of cytokines • Describe the cytokines that mediate and regulate innate immunity • Discuss the cytokines that mediate and regulate adaptive immunity • Define cytokines that stimulate hematopoiesis | - |
| 11) | • Describe immunity to extracellular bacteria • Describe immunity to intracellular bacteria • Describe immunity to fungi • Describe immunity to viruses • Describe immunity to parasites • Defining strategies for vaccine development | - |
| 12) | • Describe the ribosome structure and assembly • Describe Aminoacyl-tRNA synthetases • Definie translation and discuss basic mechanisms of translation • Discuss translational and post-translational control | - |
| 13) | • Describe the immune responses to allografts and effector mechanisms of allograft rejection • Describe prevention and treatment of allograft rejection • Define xenogeneic transplantation • Discuss the blood transfusion • Discuss the bone marrow transplantation | - |
| 14) | • Discuss the tumor antigens • Define the immune responses to tumors • Describe the evasion of immune responses by tumors • Discuss the immunotherapy for tumors | - |
| 15) | • Final Exam | - |
Sources
| Course Notes / Textbooks: | Basic Immunology: Functions and Disorders of the Immune System, 4th Edition Abul K. Abbas MBBS, Andrew H. H. Lichtman MD PhD, Shiv Pillai MBBS PhD ISBN-13: 978-1455707072 ISBN-10: 1455707074 |
| References: | Basic Immunology: Functions and Disorders of the Immune System, 4th Edition Abul K. Abbas MBBS, Andrew H. H. Lichtman MD PhD, Shiv Pillai MBBS PhD ISBN-13: 978-1455707072 ISBN-10: 1455707074 |
Course-Program Learning Outcome Relationship
| Learning Outcomes | 1 |
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| Program Outcomes | ||||||||||
| 1) Information on project management and practices in business life such as risk management and change management; awareness about entrepreneurship, innovation and sustainable development. | ||||||||||
| 2) Sufficient knowledge in mathematics, science and engineering related to their branches; the ability to apply theoretical and practical knowledge in these areas to model and solve engineering problems. | ||||||||||
| 3) The ability to identify, formulate, and solve complex engineering problems; selecting and applying appropriate analysis and modeling methods for this purpose. | ||||||||||
| 4) The ability to design a complex system, process, device or product under realistic constraints and conditions to meet specific requirements; the ability to apply modern design methods for this purpose. (Realistic constraints and conditions include such issues as economy, environmental issues, sustainability, manufacturability, ethics, health, safety, social and political issues, according to the nature of design.) | ||||||||||
| 5) Ability to develop, select and use modern techniques and tools necessary for engineering applications; ability to use information technologies effectively. | ||||||||||
| 6) Ability to design experiments, conduct experiments, collect data, analyze and interpret results for examination of engineering problems. | ||||||||||
| 7) Effective communication skills in Turkish oral and written communication; at least one foreign language knowledge. | ||||||||||
| 8) Awareness of the need for lifelong learning; access to knowledge, ability to follow developments in science and technology, and constant self-renewal. | ||||||||||
| 9) Professional and ethical responsibility. | ||||||||||
| 10) Information on the effects of engineering applications on health, environment and safety in the universal and social dimensions and the problems of the times; awareness of the legal consequences of engineering solutions. | ||||||||||
| 11) The ability to work effectively in disciplinary and multidisciplinary teams; individual work skill. | ||||||||||
Course - Learning Outcome Relationship
| No Effect | 1 Lowest | 2 Low | 3 Average | 4 High | 5 Highest |
| Program Outcomes | Level of Contribution | |
| 1) | Information on project management and practices in business life such as risk management and change management; awareness about entrepreneurship, innovation and sustainable development. | |
| 2) | Sufficient knowledge in mathematics, science and engineering related to their branches; the ability to apply theoretical and practical knowledge in these areas to model and solve engineering problems. | |
| 3) | The ability to identify, formulate, and solve complex engineering problems; selecting and applying appropriate analysis and modeling methods for this purpose. | |
| 4) | The ability to design a complex system, process, device or product under realistic constraints and conditions to meet specific requirements; the ability to apply modern design methods for this purpose. (Realistic constraints and conditions include such issues as economy, environmental issues, sustainability, manufacturability, ethics, health, safety, social and political issues, according to the nature of design.) | |
| 5) | Ability to develop, select and use modern techniques and tools necessary for engineering applications; ability to use information technologies effectively. | |
| 6) | Ability to design experiments, conduct experiments, collect data, analyze and interpret results for examination of engineering problems. | |
| 7) | Effective communication skills in Turkish oral and written communication; at least one foreign language knowledge. | |
| 8) | Awareness of the need for lifelong learning; access to knowledge, ability to follow developments in science and technology, and constant self-renewal. | |
| 9) | Professional and ethical responsibility. | |
| 10) | Information on the effects of engineering applications on health, environment and safety in the universal and social dimensions and the problems of the times; awareness of the legal consequences of engineering solutions. | |
| 11) | The ability to work effectively in disciplinary and multidisciplinary teams; individual work skill. |
Learning Activity and Teaching Methods
| Expression | |
| Brainstorming/ Six tihnking hats | |
| Lesson |
Assessment & Grading Methods and Criteria
Assessment & Grading
| Semester Requirements | Number of Activities | Level of Contribution |
| Attendance | 15 | % 10 |
| Midterms | 1 | % 50 |
| Final | 1 | % 50 |
| total | % 110 | |
| PERCENTAGE OF SEMESTER WORK | % 60 | |
| PERCENTAGE OF FINAL WORK | % 50 | |
| total | % 110 | |
Workload and ECTS Credit Grading
| Activities | Number of Activities | Duration (Hours) | Workload |
| Course Hours | 15 | 3 | 45 |
| Midterms | 1 | 2 | 2 |
| Final | 1 | 2 | 2 |
| Total Workload | 49 | ||