Dentistry
Bachelor	TR-NQF-HE: Level 6	QF-EHEA: First Cycle	EQF-LLL: Level 6

General course introduction information

Course Code:

DHF117

Course Name:

Medical Biology and Genetics

Course Semester:

Fall

Course Credits:

Theoretical	Practical	Credit	ECTS
4	2	5	6

Language of instruction:

Course Requisites:

Does the Course Require Work Experience?:

Type of course:

Compulsory

Course Level:

Bachelor

TR-NQF-HE:6. Master`s Degree

QF-EHEA:First Cycle

EQF-LLL:6. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator :

Dr.Öğr.Üyesi HİLAL EREN GÖZEL

Course Lecturer(s):

Course Assistants:

Course Objective and Content

Course Objectives:

In our theoretical courses, we start from fundamentals of cell biology and move to the molecular level of cell biology and cellular processes. We aim to teach the importance of the balance between cell division and cell death; disease relevance of cell division and cell death. In addition, we aim to give basic knowledge on other topics such as immunogenetics, genetic technologies, genetic diseases and principles of heredity. Besides, we aim to give disease relevance of these topics.
In our practical courses, we aim to enable students to learn and practice fundamental laboratory techniques that are frequently used in Medical Biology and Genetics.
When our students start their carrier, we aim to enable them to reach a certain level that they will be able to collaborate on genetics studies, to interpret the results of tests and assays that are used to diagnose a suspected patient with a genetic disease.

Course Content:

Introduction to Medical Biology
Cellular Structures / Organelles and Cytoskeleton
Cell Membrane and Membrane Transport
Introduction to Nucleic Acids
DNA Structure, Function / DNA Replication
RNA Structure and Transcription
Transcriptional Regulation
Post-Transcriptional Regulation
Genetic Codes, tRNA, rRNA / Protein Synthesis
Posttranslational Modifications
Mutations / Mutagenesis
Chromosome Abnormalities and Disorders
Cell Cycle Regulation
Cell Division
DNA Repair Mechanisms
Cell Death Regulation
Human Genome Organisation
Mendel Genetics and Inheritance Patterns
Non-Mendelian Genetics
Genetic Diseases
Cancer Genetics
Blood Genetics
Immunology
Immunogenetics
Epigenetics

Learning Outcomes

The students who have succeeded in this course;

Learning Outcomes

1 - Knowledge
Theoretical - Conceptual
1) To teach the fundamental topics of Molecular Biology and Genetics discipline
2) The aim is for students to establish a relationship between the disease information they learn in class and the cases they will encounter in the clinic.
2 - Skills
Cognitive - Practical
1) Encouraging students to - find and follow reliable websites that contain videos related to lecture topics - find and follow reliable websites that contain current news related to scientific developments
3 - Competences
Communication and Social Competence
Learning Competence
1) Enabling students to establish correct connection between the lecture topics that are covered during the year Enabling students to establish cause and effect relationship on a cellular and genetics basis
Field Specific Competence
Competence to Work Independently and Take Responsibility

Lesson Plan

Week	Subject	Related Preparation
1)	Introduction to Medical Biology	Bölüm 1 - Essential Cell Biology, Alberts; Bölüm 1 - Cell biology, Pollards
2)	Cellular Structures, Organelles, and Cytoskeleton	Bölüm 2,3,4,5-Moleküler Hücre Biyolojisi, Hasan Veysi Güneş; Chapter 1,2- The cell: Molecular Approach,Cooper GM
3)	Cell Membrane and Membrane Transport	Chapter 7, Campbell Biology
4)	Introduction to Nucleic Acids	Chapter 4-6 The cell: Molecular Approach, Cooper GM
5)	DNA Replication	Bölüm 8-Moleküler Hücre Biyolojisi, Hasan Veysi Güneş; Chapter 4, Chapter 6-The cell:Molecular Approach, Cooper GM
6)	Transcription	Bölüm 8-Moleküler Hücre Biyolojisi, Hasan Veysi Güneş; Chapter 7&8-The cell:Molecular Approach, Cooper GM
7)	Regulation of Transcription	Chapter 7: The Cell
8)	Review	Lecture Presentation Slides
9)	1. Ara Sınav
10)	Posttranscriptional Regulation	Bölüm 8-Moleküler Hücre Biyolojisi, Hasan Veysi Güneş; Chapter 7,8- The cell: Molecular Approach, Cooper GM
11)	Genetic Code/ tRNA, rRNA , Protein Synthesis	Bölüm 8-Moleküler Hücre Biyolojisi, Hasan Veysi Güneş; Chapter 7,8- The cell: Molecular Approach, Cooper GM
12)	Posttranslational modifications	Bölüm 8-Moleküler Hücre Biyolojisi-Hasan Veysi Güneş; Chapter 8,10- The cell: Molecular Approach, Cooper GM
13)	Mutations/Mutagenesis	Bölüm 8-Moleküler Hücre Biyolojisi, Hasan Veysi Güneş; Chapter 6- The cell: Molecular Approach, Cooper GM;
14)	Chromosome Abnormalities and Disorders	Tıbbi Genetiğin Esasları, Edward S. Tobias, Michael Connor, Malcolm Ferguson-Smith; Thompson & Thompson Tıbbi Genetik, Robert L. Nussbaum , Roderick R. McInnes , Huntington F. Willard; Essential Medical Genetics, Edward S. Tobias, Michael Connor, Malcolm Ferguson-Smith; Thompson & Thompson Genetics in Medicine, Robert L. Nussbaum , Roderick R. McInnes ,Huntington F. Willard
15)	Cell Cycle Regulation	Bölüm 11, Moleküler Hücre Biyolojisi, Hasan Veysi Güneş; Chapter 16, The cell: Molecular Approach, Cooper GM
16)	Cell Division	Bölüm 11, Moleküler Hücre Biyolojisi, Hasan Veysi Güneş; Chapter 16, The cell: Molecular Approach, Cooper GM
17)	Review	Lecture Presentation Slides
18)	2nd Midterm
19)	DNA Repair Mechanisms	Chapter 6- Essential Cell Biology, Alberts
20)	Regulation of Cell Death	Bölüm 11-Moleküler Hücre Biyolojisi, Hasan Veysi Güneş; Chapter 17- The cell: Molecular Approach, Cooper GM;
21)	Human Genome Organisation	Tıbbi Genetiğin Esasları, Edward S. Tobias, Michael Connor, Malcolm Ferguson-Smith; Thompson & Thompson Tıbbi Genetik, Robert L. Nussbaum , Roderick R. McInnes , Huntington F. Willard; Essential Medical Genetics, Edward S. Tobias, Michael Connor, Malcolm Ferguson-Smith; Thompson & Thompson Genetics in Medicine, Robert L. Nussbaum , Roderick R. McInnes ,Huntington F. Willard
22)	Mendelian Genetics, Inheritance Pattern	Tıbbi Genetiğin Esasları, Edward S. Tobias, Michael Connor, Malcolm Ferguson-Smith; Thompson & Thompson Tıbbi Genetik, Robert L. Nussbaum , Roderick R. McInnes , Huntington F. Willard; Essential Medical Genetics, Edward S. Tobias, Michael Connor, Malcolm Ferguson-Smith; Thompson & Thompson Genetics in Medicine, Robert L. Nussbaum , Roderick R. McInnes ,Huntington F. Willard
23)	Non-Mendelian Genetics	Tıbbi Genetiğin Esasları, Edward S. Tobias, Michael Connor, Malcolm Ferguson-Smith; Thompson & Thompson Tıbbi Genetik, Robert L. Nussbaum , Roderick R. McInnes , Huntington F. Willard; Essential Medical Genetics, Edward S. Tobias, Michael Connor, Malcolm Ferguson-Smith; Thompson & Thompson Genetics in Medicine, Robert L. Nussbaum , Roderick R. McInnes ,Huntington F. Willard
24)	Review	Lecture presentation slides
25)	3rd Midterm
26)	Genetic Diseases	Essential Medical Genetics- Edward S. Tobias, Michael Connor, Malcolm Ferguson-Smith Thompson & Thompson Genetics in Medicine- Robert L. Nussbaum , Roderick R. McInnes ,Huntington F. Willard
27)	Cancer Genetics	Tıbbi Genetiğin Esasları, Edward S. Tobias, Michael Connor, Malcolm Ferguson-Smith; Thompson & Thompson Tıbbi Genetik, Robert L. Nussbaum , Roderick R. McInnes , Huntington F. Willard; Essential Medical Genetics, Edward S. Tobias, Michael Connor, Malcolm Ferguson-Smith; Thompson & Thompson Genetics in Medicine, Robert L. Nussbaum , Roderick R. McInnes ,Huntington F. Willard
28)	Blood Genetics	Tıbbi Genetiğin Esasları, Edward S. Tobias, Michael Connor, Malcolm Ferguson-Smith; Thompson & Thompson Tıbbi Genetik, Robert L. Nussbaum , Roderick R. McInnes , Huntington F. Willard; Essential Medical Genetics, Edward S. Tobias, Michael Connor, Malcolm Ferguson-Smith; Thompson & Thompson Genetics in Medicine, Robert L. Nussbaum , Roderick R. McInnes ,Huntington F. Willard
29)	Immunology	Tıbbi Genetiğin Esasları, Edward S. Tobias, Michael Connor, Malcolm Ferguson-Smith; Thompson & Thompson Tıbbi Genetik, Robert L. Nussbaum, Roderick R. McInnes, Huntington F. Willard; Essential Medical Genetics, Edward S. Tobias, Michael Connor, Malcolm Ferguson-Smith; Thompson & Thompson Genetics in Medicine, Robert L. Nussbaum, Roderick R. McInnes, Huntington F. Willard
30)	Immunogenetics	Essential Medical Genetics- Edward S. Tobias, Michael Connor, Malcolm Ferguson-Smith Thompson & Thompson Genetics in Medicine- Robert L. Nussbaum , Roderick R. McInnes ,Huntington F. Willard
31)	Epigenetics	Tıbbi Genetiğin Esasları, Edward S. Tobias, Michael Connor, Malcolm Ferguson-Smith; Thompson & Thompson Tıbbi Genetik, Robert L. Nussbaum , Roderick R. McInnes , Huntington F. Willard; Essential Medical Genetics, Edward S. Tobias, Michael Connor, Malcolm Ferguson-Smith; Thompson & Thompson Genetics in Medicine, Robert L. Nussbaum , Roderick R. McInnes ,Huntington F. Willard
32)	Review	Lecture presentation slides

Sources

Course Notes / Textbooks:	Moleküler Hücre Biyolojisi-Hasan Veysi Güneş, İstanbul Tıp HÜCRE:Moleküler Yaklaşım, Cooper Gm, İzmir Tıp Kitapevi Tıbbi Genetiğin Esasları- Edward S. Tobias, Michael Connor, Malcolm Ferguson-Smith Thompson & Thompson Tıbbi Genetik- Robert L. Nussbaum , Roderick R. McInnes , Huntington F. Willard
References:	Moleküler Hücre Biyolojisi-Hasan Veysi Güneş, İstanbul Tıp The Cell: A Molecular Approach-Cooper GM, Sinauer Associates Inc. Essential Medical Genetics- Edward S. Tobias, Michael Connor, Malcolm Ferguson-Smith Thompson & Thompson Genetics in Medicine- Robert L. Nussbaum , Roderick R. McInnes ,Huntington F. Willard

Course-Program Learning Outcome Relationship

Learning Outcomes	1	4	2	3
Program Outcomes
1) Has the competence to appropriately evaluate signs and symptoms, relate them to diseases and conditions, and integrate them into clinical practices, including up-to-date diagnosis, treatment, and referral processes
2) Possesses the knowledge to identify dental and medical emergencies as well as high-risk and priority situations.
3) Is capable of effectively applying an analytical perspective to the use of traditional and modern tools and equipment, in accordance with up-to-date, evidence-based scientific knowledge.
4) By expressing professional ideas and experiences with all health units of the society, he/she works by taking responsibility and initiative in communication and cooperation towards improving the health level of the society
5) Knows the symptoms, signs, systemic diseases and related oral and dental diseases and applies the necessary precautions by using basic medical science knowledge in patient treatment.
6) Has the knowledge and equipment to take the necessary precautions regarding the health, safety and risks of all employees and patients.
7) Conducts professional practice, research, learning and administrative processes by utilizing information technologies
8) He/she is always open to improving his/her knowledge and skills and has adopted lifelong learning as a principle.
9) Establishes communication with patients and their relatives based on mutual trust, understanding and respect, taking into account social and cultural differences.
10) Communicates effectively and accurately with colleagues and other healthcare professionals in written and verbal form.
11) Has knowledge and equipment about providing preventive and protective oral and dental health services by considering public health, and carries out these practices.
12) Knows his/her duties and responsibilities and performs his/her profession by observing ethical and human values.

Course - Learning Outcome Relationship

No Effect	1 Lowest	2 Low	3 Average	4 High	5 Highest

	Program Outcomes	Level of Contribution
1)	Has the competence to appropriately evaluate signs and symptoms, relate them to diseases and conditions, and integrate them into clinical practices, including up-to-date diagnosis, treatment, and referral processes	4
2)	Possesses the knowledge to identify dental and medical emergencies as well as high-risk and priority situations.	3
3)	Is capable of effectively applying an analytical perspective to the use of traditional and modern tools and equipment, in accordance with up-to-date, evidence-based scientific knowledge.	1
4)	By expressing professional ideas and experiences with all health units of the society, he/she works by taking responsibility and initiative in communication and cooperation towards improving the health level of the society	2
5)	Knows the symptoms, signs, systemic diseases and related oral and dental diseases and applies the necessary precautions by using basic medical science knowledge in patient treatment.	3
6)	Has the knowledge and equipment to take the necessary precautions regarding the health, safety and risks of all employees and patients.	2
7)	Conducts professional practice, research, learning and administrative processes by utilizing information technologies	1
8)	He/she is always open to improving his/her knowledge and skills and has adopted lifelong learning as a principle.	2
9)	Establishes communication with patients and their relatives based on mutual trust, understanding and respect, taking into account social and cultural differences.	1
10)	Communicates effectively and accurately with colleagues and other healthcare professionals in written and verbal form.	2
11)	Has knowledge and equipment about providing preventive and protective oral and dental health services by considering public health, and carries out these practices.	1
12)	Knows his/her duties and responsibilities and performs his/her profession by observing ethical and human values.	1

Learning Activity and Teaching Methods

Field Study
Expression
Brainstorming/ Six tihnking hats
Individual study and homework
Lesson
Group study and homework
Lab
Reading
Problem Solving
Q&A / Discussion
Web Based Learning

Assessment & Grading Methods and Criteria

Written Exam (Open-ended questions, multiple choice, true-false, matching, fill in the blanks, sequencing)

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Committee	64	% 0
Laboratory	24	% 0
Midterms	3	% 50
Final	1	% 50
total		% 100
PERCENTAGE OF SEMESTER WORK		% 50
PERCENTAGE OF FINAL WORK		% 50
total		% 100

Workload and ECTS Credit Grading

Activities	Number of Activities	Duration (Hours)	Workload
Course Hours	32	2	64
Laboratory	12	2	24
Midterms	3	8	24
Final	1	32	32
Total Workload			144