Nutrition and Dietetics (non-thesis)
Master	TR-NQF-HE: Level 7	QF-EHEA: Second Cycle	EQF-LLL: Level 7

General course introduction information

Course Code:

BDY574

Course Name:

Biochemical Mechanisms in Diseases

Course Semester:

Spring

Course Credits:

Theoretical	Practical	Credit	ECTS
3	0	3	14

Language of instruction:

Course Requisites:

Does the Course Require Work Experience?:

Yes

Type of course:

Compulsory

Course Level:

Master

TR-NQF-HE:7. Master`s Degree

QF-EHEA:Second Cycle

EQF-LLL:7. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator :

Dr.Öğr.Üyesi HADI KARIMKHAN

Course Lecturer(s):

Course Assistants:

Course Objective and Content

Course Objectives:

Evaluate the chemical reactions occurring in living organisms and in laboratory and the properties of organic reactions.

Course Content:

This course contains;
1. Introduction to organic chemistry, C-C bonding
2. C-heteroatom bonding and properties
3. Alkanes and radicalic reactions
4. Alkenes
5. Elimination and addition reactions
6. Alkines and cycloalkanes
7. Aromatic structure and aromatic substitution reactions
8. Stereochemistry
9. Alkyl halogenures and nucleophylic substiyution reactions
10. Acid-base properties, alkohols and phenols
11. Carbonyl compounds, aldehydes and ketones
12. Nucleophylic addition to carbonyl groups
13. α-Addition to carbonyl groups
14. Carboxylic acids and their derivatives, amines and their reactions
15. Amino acids and proteins, carbohydrates, nucleic acids : DNA and RNA .

Learning Outcomes

The students who have succeeded in this course;

Learning Outcomes

1 - Knowledge
Theoretical - Conceptual
2 - Skills
Cognitive - Practical
3 - Competences
Communication and Social Competence
Learning Competence
1) 1. will be able to define the structure and functions of macromolecules (carbohydrate, protein, lipid, nucleic acid), vitamins and minerals.
2) 1.1. Recognize the general properties of monosaccharides, disaccharides and polysaccharides.
3) 1.2. Summarizes the structure and general characteristics of lipids and fatty acids, lipoproteins, sphingolipids, steroids.
4) 1.3. Describes the amino acids and their properties, the structure of proteins and the classification of proteins.
5) 1.4. Describe the structure of hormones and the mechanism of action of hormones.
6) 1.5. Summarizes the general properties of minerals and minerals.
7) 2. Explain the structural and functional importance of macromolecules in human body and discuss their relations with diseases.
8) 2.1. Explains diseases caused by enzyme deficiencies in metabolic pathways.
9) 2.2. Explains enzyme deficiencies in urea synthesis.
10) 2.3. Describe the lipid and glycogen storage diseases.
11) 2.4. Explains metabolic disorders of glucose and metabolic disorders associated with glucose metabolism disorders and atherosclerosis.
12) 3. will be able to discuss the anabolic and catabolic pathways for obtaining energy from macromolecules and the control steps in these pathways.
13) 3.1. Explains bioenergy, glycogen production and degradation, glycolysis, glycooneogenesis, citric acid cycle, pentose phosphate pathway, oxidative phosphorylation.
14) 3.2. Oxidation of fatty acids, ketogenesis lipogenesis, such as fat metabolism related issues.
15) 3.3. Understands the intersection points between all metabolic pathways and discusses energy metabolism.
16) 3.4. Explains the metabolic control mechanisms of macromolecules and the effects of enzymes and hormones in these control steps. Understands signal transmission systems.
17) 3.5. Establishes the relationship between energy metabolism and nutrition.
18) 4. Vücut homeostazizi ile ilişkili konuların önemini tanımlayayabilecektir.
19) 4.1. Establishes the relationship between buffer systems and blood pH.
20) 4.2. Understands the physical, chemical and microscopic properties of urine.
21) 4.3. Consider the relationship between urine and kidney function.
22) 4.4. Understands the importance of water in metabolism.
Field Specific Competence
Competence to Work Independently and Take Responsibility

Lesson Plan

Week	Subject	Related Preparation
1)	Energy and Metabolism	1. Lippincott Illustrated Reviews Biochemistry 2. Harper's Illustrated Biochemistry 3. Lehninger Principles of Biochemistry 4. Henry's Clinical Diagnosis and Management by Laboratory Methods, 23th
2)	glycolysis	1. Lippincott Illustrated Reviews Biochemistry 2. Harper's Illustrated Biochemistry 3. Lehninger Principles of Biochemistry 4. Henry's Clinical Diagnosis and Management by Laboratory Methods, 23th
3)	Glycolysis and Tricarboxylic acid cycle	1. Lippincott Illustrated Reviews Biochemistry 2. Harper's Illustrated Biochemistry 3. Lehninger Principles of Biochemistry 4. Henry's Clinical Diagnosis and Management by Laboratory Methods, 23th
4)	ETC Oxıdatıve Phosphorylatıon	1. Lippincott Illustrated Reviews Biochemistry 2. Harper's Illustrated Biochemistry 3. Lehninger Principles of Biochemistry 4. Henry's Clinical Diagnosis and Management by Laboratory Methods, 23th
5)	Penthose Phosphate Pathway and Gluconeogenesis	1. Lippincott Illustrated Reviews Biochemistry 2. Harper's Illustrated Biochemistry 3. Lehninger Principles of Biochemistry 4. Henry's Clinical Diagnosis and Management by Laboratory Methods, 23th
6)	Lipid Metabolism	1. Lippincott Illustrated Reviews Biochemistry 2. Harper's Illustrated Biochemistry 3. Lehninger Principles of Biochemistry 4. Henry's Clinical Diagnosis and Management by Laboratory Methods, 23th
7)	Yağ asidi ve triaçilgliserol metabolizması	1. Lippincott Illustrated Reviews Biochemistry 2. Harper's Illustrated Biochemistry 3. Lehninger Principles of Biochemistry 4. Henry's Clinical Diagnosis and Management by Laboratory Methods, 23th
8)	Midterm	1. Lippincott Illustrated Reviews Biochemistry 2. Harper's Illustrated Biochemistry 3. Lehninger Principles of Biochemistry 4. Henry's Clinical Diagnosis and Management by Laboratory Methods, 23th
9)	Fatty Acid, Ketone Body, and Triacylglycerol Metabolism Part II	1. Lippincott Illustrated Reviews Biochemistry 2. Harper's Illustrated Biochemistry 3. Lehninger Principles of Biochemistry 4. Henry's Clinical Diagnosis and Management by Laboratory Methods, 23th
10)	Hormones	1. Lippincott Illustrated Reviews Biochemistry 2. Harper's Illustrated Biochemistry 3. Lehninger Principles of Biochemistry 4. Henry's Clinical Diagnosis and Management by Laboratory Methods, 23th
11)	Vitamins I	1. Lippincott Illustrated Reviews Biochemistry 2. Harper's Illustrated Biochemistry 3. Lehninger Principles of Biochemistry 4. Henry's Clinical Diagnosis and Management by Laboratory Methods, 23th
12)	Vitamins II	1. Lippincott Illustrated Reviews Biochemistry 2. Harper's Illustrated Biochemistry 3. Lehninger Principles of Biochemistry 4. Henry's Clinical Diagnosis and Management by Laboratory Methods, 23th
13)	Minerals I	1. Lippincott Illustrated Reviews Biochemistry 2. Harper's Illustrated Biochemistry 3. Lehninger Principles of Biochemistry 4. Henry's Clinical Diagnosis and Management by Laboratory Methods, 23th
14)	Minerals II	1. Lippincott Illustrated Reviews Biochemistry 2. Harper's Illustrated Biochemistry 3. Lehninger Principles of Biochemistry 4. Henry's Clinical Diagnosis and Management by Laboratory Methods, 23th
15)	Lipoproteins	1. Lippincott Illustrated Reviews Biochemistry 2. Harper's Illustrated Biochemistry 3. Lehninger Principles of Biochemistry 4. Henry's Clinical Diagnosis and Management by Laboratory Methods, 23th
16)	Final Exam	1. Lippincott Illustrated Reviews Biochemistry 2. Harper's Illustrated Biochemistry 3. Lehninger Principles of Biochemistry 4. Henry's Clinical Diagnosis and Management by Laboratory Methods, 23th

Sources

Course Notes / Textbooks:

1. Lippincott Biyokimya: Görsel Anlatımlı Çalışma Kitapları
Yazarlar: Ferrier
Yayınevi: Nobel Tıp Kitabevleri
ISBN: 9786053354383

2. Lippincott Illustrated Reviews Biochemistry
Yazarlar: Denise Ferrier - 2017
Yayınevi: Lippincott Williams & Wilkins
ISBN: 9781496363541

3. Harper Biyokimya
Yazarlar: Murray, Bender, Weil, Botham, Kennely, Rodwell
Yayınevi: Nobel Tıp Kitabevi - 2015
ISBN: 9786053351542

4. Harper's Illustrated Biochemistry
Yazarlar: Robert K. Murray, David A Bender, Kathleen M. Botham, Peter J. Kennelly, Victor W. Rodwell and P. Anthony Weil
Yayınevi: McGraw –Hill; 29th Edition (2015)
ISBN: 978 - 0- 07-176576-3

5. Lehninger - Biyokimyanın İlkeleri
Yazarlar:Y. Murat Elçin, David Nelson , Michael M. Cox
Yayınevi: Palme Yayınevi - Akademik Kitaplar - 2018
ISBN: 9786053551393

6. Lehninger Principles of Biochemistry
Yazarlar: David L. Nelson and Michael M. Cox
Yayınevi: W. H. Freeman; 6th Edition (2012)
ISBN: 10: 071677108X

References:

1. Klinik Biyokimya El Kitabı (Hematoloji ve Seroloji Laboratuvarları İlaveli)
Yazarlar: Prof. Dr. İdris Mehmetoğlu
Yayınevi: Nobel Tıp Kitabevleri
ISBN: 9789756266373

2. Henry's Clinical Diagnosis and Management by Laboratory Methods, 23th
Yazarlar: Richard A. McPherson, Matthew R. Pincus – 2016
Yayınevi: Elsevier
ISBN: 9780323295680

3. Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition
Yazarlar: Nader Rifai - 2018
Yayınevi: Elsevier
ISBN: 9780323530446

4.Tietz Textbook of Clinical Chemistry and Molecular Diagnostics
Yazarlar: Nader Rifai, Andrea Rita Horvath, Carl T. Winttwer – 2018
Yayınevi: Elsevier
ISBN: 9780323359214

5. Marks Tıbbi Biyokimyanın Esasları
Yazarlar: Ramazan Amanvermez – 2016
Yayınevi: İstanbul Tıp Kitabevleri
ISBN: 9786054949823

6.İnsan Biyokimyası
Yazarlar: Taner Onat
Yayınevi: Palme Yayınevi - Akademik Kitaplar
ISBN: 9799758624200

Course-Program Learning Outcome Relationship

Learning Outcomes	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22
Program Outcomes
1) It has up-to-date knowledge on nutrition and dietetics.
2) It obtains information about technological tools to reach the current knowledge.
3) Using technology, it analyzes and synthesizes scientific information, develops interpretations, reports and solution proposals, and shares information with different disciplines and colleagues by communicating in line with ethical principles.
4) Taking responsibilities when faced with problems related to the field, collecting examples, bringing solution proposals, using teamwork and communication and information technology.
5) Adopts lifelong learning principles and evaluates, discusses, interprets statistically based on the statistically based practice of scientific articles in the direction of ethical principles with a critical approach.
6) It contributes, conducts, manages and evaluates the scientific information in the direction of ethical principles, taking into account the opinions, the individual and the society, and will direct the national and international nutrition plans and policies.

Course - Learning Outcome Relationship

No Effect	1 Lowest	2 Low	3 Average	4 High	5 Highest

	Program Outcomes	Level of Contribution
1)	It has up-to-date knowledge on nutrition and dietetics.
2)	It obtains information about technological tools to reach the current knowledge.
3)	Using technology, it analyzes and synthesizes scientific information, develops interpretations, reports and solution proposals, and shares information with different disciplines and colleagues by communicating in line with ethical principles.
4)	Taking responsibilities when faced with problems related to the field, collecting examples, bringing solution proposals, using teamwork and communication and information technology.
5)	Adopts lifelong learning principles and evaluates, discusses, interprets statistically based on the statistically based practice of scientific articles in the direction of ethical principles with a critical approach.
6)	It contributes, conducts, manages and evaluates the scientific information in the direction of ethical principles, taking into account the opinions, the individual and the society, and will direct the national and international nutrition plans and policies.

Learning Activity and Teaching Methods

Expression
Brainstorming/ Six tihnking hats
Individual study and homework
Lesson
Lab
Reading
Homework

Assessment & Grading Methods and Criteria

Written Exam (Open-ended questions, multiple choice, true-false, matching, fill in the blanks, sequencing)
Oral Examination
Homework
Application

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Laboratory	12	% 20
Homework Assignments	12	% 10
Midterms	12	% 30
Final	12	% 40
total		% 100
PERCENTAGE OF SEMESTER WORK		% 60
PERCENTAGE OF FINAL WORK		% 40
total		% 100

Workload and ECTS Credit Grading

Activities	Number of Activities	Duration (Hours)	Workload
Course Hours	16	2	32
Laboratory	16	2	32
Application	16	2	32
Homework Assignments	16	1	16
Midterms	1	1	1
Final	1	1	1
Total Workload			114